In the Name of Science: A History of Secret Programs, Medical Research, and Human Experimentation

ISBN 13: 9780965864992
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Seller Inventory GRP Andrew Goliszek. Publisher: St. Martin's Press , This specific ISBN edition is currently not available. View all copies of this ISBN edition:. Synopsis Good. Clean text. No writing. First edition. Learn more about this copy. Other Popular Editions of the Same Title. Search for all books with this author and title. Customers who bought this item also bought. The status of prison research has not changed, however [ 15 ]. Our understanding of a broad range of infectious diseases has benefited greatly from studies performed during the past hundred years that have involved thousands of healthy volunteers.

The volunteers offered themselves to investigators, who injected, fed, sprayed, and prodded them to induce infectious diseases. Their great contributions to the knowledge, control, and treatment of these infectious diseases have been underappreciated. Experimentation that involves inducing disease continues today, although it is generally limited to situations in which risks are generally characterized and controllable.

Research in such areas as malaria, benign respiratory illnesses, and even hepatitis will continue. Given the importance of further study, one might foresee studies involving cutaneous anthrax or GB virus C hepatitis G virus in which an appropriate risk-benefit ratio and voluntary participation might be achieved; the risk involved in the study of smallpox and HIV infection may yet be too great. Throughout the 20th century, the protection of human subjects improved as a result greater attention being given to ensuring that there is adequate informed consent, voluntary participation, just distribution of the burdens and benefits of research, and prevention of disproportionate exposure to risk.

Although the scientific imperative is often great, future research must strike an adequate balance between the risks to the participant and the benefits to society. We thank Susan Lederer, for her review of the manuscript and suggestions for additional historical materials; Robert DeSalle and Robert J. Levine, for their review of the manuscript; and Anne Monroe, for her research assistance.

Oxford University Press is a department of the University of Oxford. It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide. Sign In or Create an Account. Sign In. Advanced Search. Article Navigation. Close mobile search navigation Article Navigation. Volume Article Contents. Upper Respiratory Infections.

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Reprints or correspondence: Dr. Oxford Academic. Google Scholar. Kent A. Cite Citation. Permissions Icon Permissions. Abstract The current care of patients with infectious diseases owes a tremendous debt to healthy volunteers who allowed investigators to induce disease in them for the study of transmission, natural history, and treatment.

In the Name of Science A History of Secret Programs Medical Research and Human Experimentation

Open in new tab Download slide. Findings from representative volunteer studies of hepatitis virus. Findings from 4 representative volunteer studies of the common cold. Findings from 4 representative volunteer studies of malaria. Search ADS. Use of the oral neuraminidase inhibitor oseltamivir in experimental human influenza: randomized controlled trials for prevention and treatment. Safety and efficacy of the neuraminidase inhibitor GG in experimental human influenza. National Bioethics Advisory Commission. Ethical and policy issues in research involving human participants: report and recommendations of the National Bioethics Advisory Commission.

Google Preview. Royal College of Physicians. Research on healthy volunteers: a report of the royal college of physicians. Commentary: safety of participants in non-therapeutic research must be ensured. Untreated syphilis in the male Negro: background and current status of patients in the Tuskegee study.

Virus jaundice: epidemic hepatitis in relation to immunization with human serum [in Russian].

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Jaundice occurring one to four months after transfusion of blood or plasma. Jaundice in army personnel in the western region of the United States and its relation to vaccination against yellow fever. Jaundice following yellow-fever immunisation: transmission by intranasal instillation.

Unethical human experimentation

Hepatitis due to the injection of homologous blood products in human volunteers. Homologous serum hepatitis and infectious epidemic hepatitis: studies in volunteers bearing on immunological and other characteristics of the etiological agents. Oral administration to volunteers of feces from patients with homologous serum hepatitis and infectious epidemic hepatitis. Homologous serum hepatitis and infectious epidemic hepatitis: experimental study of immunity and cross immunity in volunteers—a preliminary report.

Commission on Acute Respiratory Diseases. The transmission of primary atypical pneumonia to human volunteers II: results of inoculation.

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Commision on Acute Respiratory Diseases. The transmission of primary atypical pneumonia to human volunteers III: clinical features. Studies in the common cold IV: experimental transmission of the common cold to anthropoid apes and human beings by means of a filterable agent. Transmission of the common cold to volunteers under controlled conditions III: the effect of chilling of the subjects upon susceptibility.

Transmission of experimental rhinovirus: colds in volunteer married couples. Increased levels of interleukin-1 are detected in nasal secretions of volunteers during experimental rhinovirus colds. Transmission of the common cold to volunteers under controlled conditions IV: specific immunity to the common cold.

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Prison malaria; convicts expose themselves to disease so doctors can study it. Multidrug-resistant strain of Plasmodium falciparum from eastern Colombia. Non-A, non-B hepatitis after experimental transmission of malaria by inoculation of blood. Laboratory methods for the conduct of experimental malaria challenge of volunteers.

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Clinical manifestations of Plasmodium falciparum malaria experimentally induced by mosquito challenge. Plasmodium falciparum —infected Anopheles stephensi inconsistently transmit malaria to humans. Quantitation of Plasmodium falciparum sporozoites transmitted in vitro by experimentally infected Anopheles gambiae and Anopheles stephensi. Safety and efficacy of a recombinant DNA Plasmodium falciparum sporozoite vaccine. Safety, immunogenicity, and efficacy of a malaria sporozoite vaccine administered with monophosphoryl lipid A, cell wall cytoskeleton of mycobacteria, and squalene as adjuvant.

Antisporozoite vaccine for malaria: experimental basis and current status. Mefloquine failure in a case of falciparum malaria induced with a multi-drug resistant isolate in a non-immune subject. Azithromycin prophylaxis against a chloroquine-resistant strain of Plasmodium falciparum. The Belmont report: ethical principles and guidelines for the protection of human subjects of research.

A serological follow-up of the epidemic of post-vaccination hepatitis in the united states army. Subjected to science: human experimentation in America before the Second World War.

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Sign Up Join. Many of the infants experienced diarrhea and anal bleeding. Human experimentation continued throughout the Cold War. In related studies from to , Dr. Retrieved November 13, Retrieved 23 March

Research involving prisoners: report and recommendations. Issue Section:. Download all figures. Comments 0. Add comment Close comment form modal. I agree to the terms and conditions. You must accept the terms and conditions. Add comment Cancel. Submit a comment. Comment title. You have entered an invalid code. Submit Cancel. Thank you for submitting a comment on this article. Your comment will be reviewed and published at the journal's discretion.

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